Mastocytosis Mast Cell Abundance Causes Systemic Mastocytosis, Mastocytoma, Urticaria Pigmentosa

Mastocytosis means you have an over abundance of mast cells. Mast cells may be abundantly found in your skin, lymph nodes, liver, spleen, bone, lung lining, stomach lining and intestinal lining.

Mastocytosis can occur systemically or cutaneously. Systemic mastocytosis is caused by over abundance of mast cells in your organ tissue. And mast cells accumulating in your skin tissue typically causes what’s known as urticaria pigmentosa. Mastocytoma refers to mask cell accumulation in a localized skin area.

A mast cell is best known for inducing immediate inflammation in response to an allergen during an allergic reaction. The mast cell release of histamine and other chemicals. i.e. leukotrienes and prostaglandins, is what triggers your:

Mast cell chemical release can also be a cause of acid indigestion, palpitationsheadacheshypotension or even anaphylaxis.

Mast cells appear to play a role in innate immunity, defense against parasitic infections, adjusting your immune system response, wound healing and the growth of blood vessels as well.

When you have an abundance of mast cells you may experience some of the symptoms typical of an allergic reaction, as mentioned above. Yet, mastocytosis may cause additional symptoms of:

Many with systemic mastocytosis also develop urticaria pigmentosa. However, mastocytoma and urticaria pigmentosa usually don’t develop into systemic mastocytosis.

There’s no treatment available to reduce your mast cell numbers. Fortunately, mastocytoma and urticaria pigmentosa frequently resolve on their own.

There are several medications which can be helpful toward relieving symptoms of systemic mastocytosis, such as:

Having too few mast cells likely is incompatible with life, yet having an abundance doesn’t shorten life. Just causes some unpleasant symptoms.

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